HCID 86709904, compound → HCID 70673852, compound

HRID 341343Notes

Reaction equation

HRID 341343 reaction equation
[CH3:1][Si:2]1([CH2:7][CH:8]([C:13]#[N:14])[CH2:9][C:10]([OH:12])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3]1>[OH-].[OH-].[Pd+2]>[NH2:14][CH2:13][CH:8]([CH2:7][Si:2]1([CH3:1])[CH2:6][CH2:5][CH2:4][CH2:3]1)[CH2:9][C:10]([OH:12])=[O:11]

Participants

3

Reactant 1

HCID 86709904HCID 86709904, compound

Product 1

HCID 70673852HCID 70673852, compoundYield 48.4%

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

4-(1-Methyl-1-silacyclopentan-1-yl)-3-cyanobutanoic acid (555 mg, 2.63 mmol) was subjected to catalytic reduction in the presence of Pd(OH)2 in the same manner as that of Example 20, the solvent was evaporated, and the residue was recrystallized to obtain 4-amino-3-[(1-methyl-1-silacyclopentan-1-yl)methyl]butanoic acid (274 mg, 48%) mentioned in the title as colorless powdery crystals.

Workup

  1. customthe solvent was evaporated
  2. customthe residue was recrystallized

Sources & evidence

ORD record
ord-d7348cbe4d794038979572ebcd2c6ec9
Source dataset
uspto-grants-2014_11
Patent number
US08895769B2

Reaction notes

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