HRID34143

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID85976836

未命名化合物

结构：CC(C)(C)OC(=O)CCC[C@H](N)c1nc2cc(Cl)ccc2[nH]1

HCID178450996

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CCC[C@H](Nc1ncnc2cc(C(=O)N3CCCC3)c(Cl)cc12)c1nc2cc(Cl)ccc2[nH]1

HCID178450998

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 2d from 4,6-dichloro-7-(pyrrolidin-1-yl-carbonyl)-quinazoline, (S)-1-(5-chloro-1H-benzimidazol-2-yl)-4-(tert.-butyloxycarbonyl)-butylamine and triethylamine in N,N-dimethylformamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0bd5a76f841a4409abaf700c7ef8b404
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07429597B2
来源说明: uspto-grants-2008_09

反应 SMILES

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])=[C:9]([Cl:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:20][C:21]1[CH:41]=[CH:40][C:24]2[NH:25][C:26]([C@@H:28]([NH2:39])[CH2:29][CH2:30][CH2:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[N:27][C:23]=2[CH:22]=1.C(N(CC)CC)C>CN(C)C=O>[Cl:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[C:13]([N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:14])[N:5]=[CH:4][N:3]=[C:2]2[NH:39][C@H:28]([C:26]1[NH:25][C:24]2[CH:40]=[CH:41][C:21]([Cl:20])=[CH:22][C:23]=2[N:27]=1)[CH2:29][CH2:30][CH2:31][C:32]([O:34][C:35]([CH3:37])([CH3:36])[CH3:38])=[O:33]