Triethylamine → HCID 178450997, compound

HRID 34144Notes

Reaction equation

HRID 34144 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:13]([N:15]3[CH2:19][CH:18]=[CH:17][CH2:16]3)=[O:14])=[C:9]([Cl:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:20][C:21]1[CH:41]=[CH:40][C:24]2[NH:25][C:26]([C@@H:28]([NH2:39])[CH2:29][CH2:30][CH2:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[N:27][C:23]=2[CH:22]=1.C(N(CC)CC)C>CN(C)C=O>[Cl:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[C:13]([N:15]1[CH2:19][CH:18]=[CH:17][CH2:16]1)=[O:14])[N:5]=[CH:4][N:3]=[C:2]2[NH:39][C@H:28]([C:26]1[NH:25][C:24]2[CH:40]=[CH:41][C:21]([Cl:20])=[CH:22][C:23]=2[N:27]=1)[CH2:29][CH2:30][CH2:31][C:32]([O:34][C:35]([CH3:37])([CH3:36])[CH3:38])=[O:33]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 866326954,6-Dichloro-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazolineHCID 178450996HCID 178450996, compound

Product 1

HCID 178450997HCID 178450997, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 2d from 4,6-dichloro-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazoline, (S)-1-(5-chloro-1H-benzimidazol-2-yl)-4-(tert.-butyloxycarbonyl)-butylamine and triethylamine in N,N-dimethylformamide.

Sources & evidence

ORD record
ord-6c470c0c64c948e5bb5ed7450105d70e
Source dataset
uspto-grants-2008_09
Patent number
US07429597B2

Reaction notes

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