Triethylamine → HCID 54328399, compound

HRID 341758Notes

Reaction equation

HRID 341758 reaction equation
[OH:1][CH:2]1[S:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]1=[O:13].C(N(CC)CC)C.[CH:21]([N:24]=[C:25]=[O:26])([CH3:23])[CH3:22]>C(Cl)(Cl)Cl>[CH:21]([NH:24][C:25]([O:1][CH:2]1[S:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]1=[O:13])=[O:26])([CH3:23])[CH3:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 61277Isopropyl isocyanateHCID 53729413HCID 53729413, compound

Product 1

HCID 54328399HCID 54328399, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A stirred solution of 5-hydroxy-3-phenyl-4-thiazolidinone (prepared as in Preparative Example 17 above) (0.24 g) and triethylamine (0.01 ml) in chloroform (5 ml) was treated with iso-propyl isocyanate (0.116 g). The mixture was stirred for 4 hours, then evaporated under reduced pressure. Recrystallisation of the solid residue from diethyl ether/hexane afforded the title compound as colourless needles, yield 0.14 g, mp 130°-132° C.

Workup

  1. customevaporated under reduced pressure
  2. customRecrystallisation of the solid residue from diethyl ether/hexane

Sources & evidence

ORD record
ord-da72fe2ce93a4195a08c46bad7f13017
Source dataset
uspto-grants-1999_01
Patent number
US05856273

Reaction notes

Loading…