反应详情

adding a solution of hydrogen chloride in isopropanol to a toluene solution of [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol or its enantiomer at about 10° to about 15° C. and maintaining a reaction temperature of about 10° to about 25° C. to form [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol hydrochloride or its enantiomer;

1. temperaturemaintaining a reaction temperature of about 10° to about 25° C.