反应详情

1.35 g of 7-(4-bromo-but-2-enyloxy)-4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazine are dissolved in 50 ml of acetone and treated with 3.83 ml of N-allyl-methyl-amine and 1.28 g of potassium carbonate. The mixture is stirred and subsequently filtered. After concentration the filtrate is chromatographed over silica gel with toluene/acetone/triethylamine (92:7:1). There are obtained 1.09 g of (E)-allyl-[4-[4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazin-7-yloxy]-but-2-enyl]-methyl-amine which is converted into the fumarate, MS: m/e 427 (M+H+, 1 Br).

1. filtrationsubsequently filtered
2. concentrationAfter concentration the filtrate
3. customis chromatographed over silica gel with toluene/acetone/triethylamine (92:7:1)