Water → HCID 11102507, compound

HRID 342229Notes

Reaction equation

HRID 342229 reaction equation
[CH2:1]([N:4]([CH3:30])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[CH:14][C:15]([C:19]([C:23]2[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=2)(O)[CH:20]=[CH2:21])=[C:16]([OH:18])[CH:17]=1)[CH:2]=[CH2:3].O>CC1C=CC=CC=1C>[CH2:1]([N:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[C:16]2[C:15]([C:19]([C:23]3[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=3)=[CH:20][CH2:21][O:18]2)=[CH:14][CH:13]=1)[CH3:30])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 962WaterHCID 11070762HCID 11070762, compound

Product 1

HCID 11102507HCID 11102507, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 0.26 g of (RS)-5-[6-(allyl-methyl-amino)-hexyloxy]-2-[1-(4-bromo-phenyl)-1-hydroxy-allyl]-phenol in 50 ml of o-xylene is boiled at 170° C. on a water separator for 2 hrs., evaporated and the residue is purified over silica gel with methylene chloride/methanol 95:5. There is obtained 0.18 g of allyl-[6-[4-(4-bromo-phenyl)-2H-chromen-7-yloxy]-hexyl]-methyl-amine, MS: m/e 456 (M+H+, 1 Br).

Workup

  1. customfor 2 hrs
  2. custom, evaporated
  3. customthe residue is purified over silica gel with methylene chloride/methanol 95:5

Sources & evidence

ORD record
ord-43d3880144fd466285a13507eab8ad68
Source dataset
uspto-grants-1999_01
Patent number
US05856503

Reaction notes

Loading…