反应详情

A mixture of 2-methyl-7-nitro-3-phthalimidomethylbenzo[b]furan (575 mg) and hydrazine monohydrate (172 mg) in ethanol (10 ml) was refluxed for 5 hours. The reaction mixture was cooled, acidified with 1N-hydrochloric acid and filtered. The filtrate was neutralized with aqueous saturated sodium bicarbonate and the ethanol in the mixture was evaporated in vacuo. The separated solid was collected, washed with water and dried to give 3-aminomethyl-2-methyl-7-nitrobenzo[b]furan (290 mg).

1. temperaturewas refluxed for 5 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customthe ethanol in the mixture was evaporated in vacuo
5. customThe separated solid was collected
6. washwashed with water
7. customdried