反应详情

温度

70 °C

A mixture of 7-amino-2-ethyl-3-methylbenzo[b]furan (858 mg), 2,6-dichlorobenzoyl chloride (1.23 g) and triethylamine (1.23 g) in 1,2-dichloroethane (17 ml) was stirred for 3 hours at 70° C. The mixture was diluted with dichloromethane, washed with diluted hydrochloric acid and brine, dried over sodium sulfate, and evaporated in vacuo to give a solid. The residue solid was crystallized from a mixture of ethanol (20 ml) and water (2 ml) to give 7-(2,6-dichlorobenzoylamino)-2-ethyl-3-methylbenzo[b]furan (610 mg).

1. washwashed with diluted hydrochloric acid and brine
2. dry with materialdried over sodium sulfate
3. customevaporated in vacuo
4. customto give a solid
5. customThe residue solid was crystallized from a mixture of ethanol (20 ml) and water (2 ml)