Hydrochloric Acid → HCID 70200669, compound

HRID 342457Notes

Reaction equation

HRID 342457 reaction equation
C(OC([NH:8][C:9]1[CH:19]=[C:18]([NH:20][C:21](=[O:30])[C:22]2[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=2[Cl:29])[C:12]2[O:13][C:14]([CH3:17])=[C:15]([CH3:16])[C:11]=2[CH:10]=1)=O)(C)(C)C.Cl.C(OCC)C>C(OCC)(=O)C>[ClH:28].[NH2:8][C:9]1[CH:19]=[C:18]([NH:20][C:21](=[O:30])[C:22]2[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=2[Cl:29])[C:12]2[O:13][C:14]([CH3:17])=[C:15]([CH3:16])[C:11]=2[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 67557399HCID 67557399, compound

Product 1

HCID 70200669HCID 70200669, compoundYield 183.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 5-(tert-butoxycarbonylamino)-7-(2,6-dichlorobenzoylamino)-2,3-dimethylbenzo[b]furan (1.56 g) in 4N-hydrogen chloride in ethyl acetate (10 ml) was stirred at ambient temperature for 1 hour and to the reaction mixture was added diethyl ether. The separated solid was collected, washed with diethyl ether and dried to give 5-amino-7-(2,6-dichlorobenzoylamino)-2,3-dimethylbenzo[b]furan hydrochloride (1.23 g).

Workup

  1. customThe separated solid was collected
  2. washwashed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-a069e5734460471088087371eeb84799
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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