Hydrogen Peroxide → HCID 70202654, compound

HRID 342467Notes

Reaction equation

HRID 342467 reaction equation
[OH:1]O.[Cl:3][C:4]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:5]=1[C:6]([NH:8][C:9]1[C:17]2[O:16][C:15]3[CH2:18][CH2:19][S:20][CH2:21][C:14]=3[C:13]=2[CH:12]=[CH:11][CH:10]=1)=[O:7].O>FC(F)(F)C(O)=O>[Cl:26][C:22]1[CH:23]=[CH:24][CH:25]=[C:4]([Cl:3])[C:5]=1[C:6]([NH:8][C:9]1[C:17]2[O:16][C:15]3[CH2:18][CH2:19][S:20](=[O:1])[CH2:21][C:14]=3[C:13]=2[CH:12]=[CH:11][CH:10]=1)=[O:7]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 70196713HCID 70196713, compound

Product 1

HCID 70202654HCID 70202654, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent2×

Procedure

A solution of hydrogen peroxide in trifluoroacetic acid (1M, 0.32 ml) wa s added to a solution of 6-(2,6-dichlorobenzoylamino)-3,4-dihydro-1H-thiopyrano-[4,3-b]benzofuran (120 mg) in trifluoroacetic acid (2.5 ml) at 4° C. The mixture was stirred at ambient temperature for 30 minutes and to the mixture was added water. The separated solid was collected and dried. The obtained solid was suspended in hot ethanol and to the mixture was added water. The mixture was cooled and the separated solid was collected to give 6-(2,6-dichlorobenzoylamino)-3,4-dihydro-1H-thiopyrano[4, 3-b]-benzofuran 2-oxide (70 mg).

Workup

  1. customThe separated solid was collected
  2. customdried
  3. additionwas added water
  4. temperatureThe mixture was cooled
  5. customthe separated solid was collected

Sources & evidence

ORD record
ord-073f533c1e514046b8dc77376e2b6252
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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