HCID 70196728, compound → HCID 70200722, compound

HRID 342472Notes

Reaction equation

HRID 342472 reaction equation
[Cl:1][C:2]1[C:21]([CH2:22][O:23]COCCOC)=[CH:20][CH:19]=[C:18]([Cl:30])[C:3]=1[C:4]([NH:6][C:7]1[C:12]2[O:13][C:14]([CH3:17])=[C:15]([CH3:16])[C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:5]>Cl>[Cl:1][C:2]1[C:21]([CH2:22][OH:23])=[CH:20][CH:19]=[C:18]([Cl:30])[C:3]=1[C:4]([NH:6][C:7]1[C:12]2[O:13][C:14]([CH3:17])=[C:15]([CH3:16])[C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 1

HCID 70196728HCID 70196728, compound

Product 1

HCID 70200722HCID 70200722, compoundYield 88.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 7-[2,6-dichloro-3-(2-methoxyethyl)oxymethoxymethylbenzoylamino]-2,3-dimethylbenzo[b]furan (305 mg) in 10% methanolic hydrogen chloride (4.5 m.l) was refluxed for 1 hour. The reaction mixture was cooled and the separated solid was collected to give 7-(2,6-dichloro-3-hydroxymethylbenzoylamino)-2,3-dimethylbenzo[b]furan (217 mg).

Workup

  1. temperatureThe reaction mixture was cooled
  2. customthe separated solid was collected

Sources & evidence

ORD record
ord-e9301500c12e49afbb5c3cd1998e4255
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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