Hydrochloric Acid → HCID 178436498, compound

HRID 342478Notes

Reaction equation

HRID 342478 reaction equation
C1O[C:4]2([CH2:9][CH2:8][CH:7]([NH:10][C:11]3[C:16](Cl)=[C:15]([CH2:18][CH3:19])[N:14]=[CH:13][N:12]=3)[CH2:6][CH2:5]2)[O:3]C1.[ClH:21]>O1CCCC1.C1(C)C=CC=CC=1>[Cl:21][C:11]1([NH:10][CH:7]2[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]2)[CH:16]=[C:15]([CH2:18][CH3:19])[N:14]=[CH:13][NH:12]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57130834HCID 57130834, compound

Product 1

HCID 178436498HCID 178436498, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8028TetrahydrofuranSolvent

Procedure

70 g (0.235 mol) of 4-(5-chloro-6-ethylpyrimidin-4-ylamino) cyclohexanone ethylene ketal (starting material for Example C) were stirred at 50° C. for 8 hours in a mixture of 250 ml of tetrahydrofuran and 250 ml of 2N hydrochloric acid. For work-up, the mixture was diluted with 250 ml of toluene, and the organic phase was extracted by stirring with sodium carbonate solution and water. Stripping off the solvent mixture gave 53.4 g (90% of theory) of product, which can be reacted without further purification.

Workup

  1. extractionthe organic phase was extracted
  2. customgave 53.4 g (90% of theory) of product, which
  3. customcan be reacted without further purification

Sources & evidence

ORD record
ord-78bcec72372044039afc9295dfbf878d
Source dataset
uspto-grants-1999_01
Patent number
US05859009

Reaction notes

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