NSC251211 → HCID 15308300, compound

HRID 342490Notes

Reaction equation

HRID 342490 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH2:12][CH2:13][C:14](=[O:17])[NH:15][N:16]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].CC(C)([O-])C.[K+].[C:24]([NH:32][C:33]1[CH:40]=[CH:39][C:36]([CH2:37]Cl)=[CH:35][CH:34]=1)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1>C1COCC1>[C:24]([NH:32][C:33]1[CH:40]=[CH:39][C:36]([CH2:37][N:15]2[C:14](=[O:17])[CH2:13][CH2:12][C:11]([C:5]3[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)=[N:16]2)=[CH:35][CH:34]=1)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1

Participants

5

Reactant 3

HCID 317789NSC251211HCID 15308299HCID 15308299, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 15308300HCID 15308300, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 4.70 g of 6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one ("A") in 150 ml of THF is treated with 2.24 g of potassium tert-butoxide and the mixture is stirred for 30 minutes. 7.32 g of 4-nicotinoylaminobenzyl chloride is added and the mixture is subsequently stirred at room temperature for 10 hours. The solvent is removed and the residue is worked up in the customary manner. 2-(4-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one is obtained.

Workup

  1. stirringthe mixture is subsequently stirred at room temperature for 10 hours
  2. customThe solvent is removed

Sources & evidence

ORD record
ord-45fb26bec2114b02807d446a4cc103e3
Source dataset
uspto-grants-1999_01
Patent number
US05859008

Reaction notes

Loading…