反应详情

A solution of 13.4 mL (147 mmol) of aniline in 30.7 mL of triethylamine was slowly added to a solution containing 25.1 g (147 mmol) of 3-methoxybenzoyl chloride in methylene chloride. The resulting reaction mixture was reacted for approximately thirty minutes and then diluted with 1N sodium bicarbonate. The resultant layers were separated and the organic layer was washed sequentially with water, 1M sodium hydroxide and then brine, dried over sodium sulfate, filtered and then reduced to dryness under reduced pressure to provide 31.5 g of an off-white solid.

1. customThe resulting reaction mixture
2. customwas reacted for approximately thirty minutes
3. customThe resultant layers were separated
4. washthe organic layer was washed sequentially with water, 1M sodium hydroxide
5. dry with materialbrine, dried over sodium sulfate
6. filtrationfiltered