反应详情

To a 50 ml round bottomed flask with stirring bar and an argon inlet was added CH3Cl (10 ml), THF (5 ml), 1-o-tolyl-propan-1-one (318 mg, 2.14 mmol, and pyridium bromide perbromide (735 mg, 2.36 mmol). This solution was stirred at ambient temperature for 2 h. The reaction mixture was washed with 5% aqueous HCl, H2O, and brine. Drying (MgSO4), filtration and removal of sovent in vacuo gave an oil. This material was chromatographed (Silica gel, 5% EtOAc/Hexane) to affort the title product.

1. stirringThis solution was stirred at ambient temperature for 2 h
2. washThe reaction mixture was washed with 5% aqueous HCl, H2O, and brine
3. customDrying
4. filtration(MgSO4), filtration and removal of sovent in vacuo
5. customgave an oil
6. customThis material was chromatographed (Silica gel, 5% EtOAc/Hexane)