4-(N-formylaminomethyl)benzophenone → (4-(Aminomethyl)phenyl)(phenyl)methanone

HRID 342792Notes

Reaction equation

HRID 342792 reaction equation
C([NH:3][CH2:4][C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1)=O>Cl.C(O)C>[NH2:3][CH2:4][C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 537210824-(N-formylaminomethyl)benzophenone

Product 1

HCID 2760963(4-(Aminomethyl)phenyl)(phenyl)methanone

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

70 g of 4-(N-formylaminomethyl)benzophenone are stirred in a mixture of 40 g of concentrated hydrochloric acid and 100 g of ethanol for 5 hours at 50° C. The alcohol is then removed by distillation and the pH is adjusted to 10 with sodium hydroxide solution. 4-aminomethylbenzophenone precipitates as an oil.

Workup

  1. customThe alcohol is then removed by distillation
  2. custom4-aminomethylbenzophenone precipitates as an oil

Sources & evidence

ORD record
ord-8df23931cdc646c2a417537deeb17402
Source dataset
uspto-grants-1999_01
Patent number
US05859084

Reaction notes

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