1-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-4-[(4-piperidinyl)acetyl]piperazine → HCID 69847253, compound

HRID 343340Notes

Reaction equation

HRID 343340 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:9]=3[CH:8]([N:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[CH2:20][CH2:19]3)[C:5]2=[N:6][CH:7]=1.C1(C([C:46]2[CH:57]=[CH:56][CH:55]=[CH:54][C:47]=2[C:48]([N:50]=[C:51]([O-:53])[O-])=[O:49])C2C=CC=CC=2)C=CC=CC=1>CC(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:9]=3[CH:8]([N:18]3[CH2:19][CH2:20][N:21]([C:24](=[O:32])[CH2:25][CH:26]4[CH2:31][CH2:30][N:29]([C:51](=[N:50][C:48](=[O:49])[C:47]5[CH:46]=[CH:57][CH:56]=[CH:55][CH:54]=5)[O:53][C:9]5[CH:16]=[CH:15][CH:14]=[CH:13][CH:10]=5)[CH2:28][CH2:27]4)[CH2:22][CH2:23]3)[C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 107682201-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-4-[(4-piperidinyl)acetyl]piperazine2×HCID 178523930HCID 178523930, compound

Product 1

HCID 69847253HCID 69847253, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

1-(3-Bromo-8-chloro-6,11-dihydro-5 H-benzo[5,6]cyclo-hepta[1,2-b] pyridin-11-yl)-4-[(4-piperidinyl)acetyl]piperazine (1 equivalent) (Formula 47.0, prepare as described in Preparative Example 11) and diphenylmethylbenzoylcarbonimidate (1.2 equivalents) [prepare as described in: A. Buschauer, Arch. Pharm., 377-378 (1987)] are dissolved in 2-propanol and the mixture is heated as described in Example 1 above to give the title compound (Formula 24.0).

Workup

  1. temperaturethe mixture is heated

Sources & evidence

ORD record
ord-04eef621e3054e09b55753e57e68eb10
Source dataset
uspto-grants-1999_01
Patent number
US05861395

Reaction notes

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