反应详情

温度

80 °C

To a stirred solution of purine (300 mg, 2.5 mmol) in N,N-dimethylacetamide (30 mL) was added 4-bromomethyl-N-methyl-N-cyclohexyl benzamide (852 mg, 2.75 mmol). After stirring at 80° C. for 7 hr, the reaction was stirred at room temperature for 16 hr. The solvent was removed under reduced pressure and the residue (510 mg) chromatographed (silica gel, CH2Cl2 /MeOH/90/10) to give 9 (310 mg, 35%); m.p. 229°-30° C. Anal calcd. for C20H23N5O: C, 68.71; H, 6.61; N, 20.05. Found: C, 68.24; H, 6.79; N, 19.77.

1. stirringthe reaction was stirred at room temperature for 16 hr
2. customThe solvent was removed under reduced pressure
3. customthe residue (510 mg) chromatographed (silica gel, CH2Cl2 /MeOH/90/10)