Lithium Hydroxide → HCID 178489168, compound

HRID 343530Notes

Reaction equation

HRID 343530 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+].O1CCCC1.O>Cl.ClCCl>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][N:15]=[N:16][N:17]=2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Participants

6

Reactant 3

HCID 3939Lithium HydroxideHCID 21881883Oxolane--water (1/1)HCID 178497409HCID 178497409, compound

Product 1

HCID 178489168HCID 178489168, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 6344DichloromethaneSolvent

Procedure

Combine methyl 2-methoxy-5-(1H-tetrazol-5-yl)benzoate (1 mmol) and lithium hydroxide (1.1 mmol) in 1/1 tetrahydrofuran/water (5 mL). After 24 hours, dilute the reaction mixture with a 0.5M aqueous hydrochloric acid solution and dichloromethane. Separate the layers and extract the aqueous layer three times with dichloromethane. Combine the organic layers, dry over MgSO4, filter, and evaporate in vacuo to give the title compound.

Workup

  1. customSeparate the layers
  2. extractionextract the aqueous layer three times with dichloromethane
  3. dry with materialdry over MgSO4
  4. filtrationfilter
  5. customevaporate in vacuo

Sources & evidence

ORD record
ord-c1672ff1b1dd487cb2c1ae949aefbe18
Source dataset
uspto-grants-1999_01
Patent number
US05861417

Reaction notes

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