反应详情

60% Sodium hydride (1.2 g) was suspended in tetrahydrofuran (30 ml), and benzyl alcohol (3.0 g) was added under ice-cooling with stirring. The mixture was stirred at room temperature for 30 min, and again ice-cooled. 1,4-Dibromobutane (6.0 g) was added and the mixture was stirred for 3 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried and the solvent was evaporated under reduced pressure to give 3.8 g of 4-benzyloxybutyl bromide.

1. temperaturecooling
2. stirringThe mixture was stirred at room temperature for 30 min
3. temperatureagain ice-cooled
4. stirringthe mixture was stirred for 3 hr
5. extractionthe mixture was extracted with ethyl acetate
6. washThe organic layer was washed with brine
7. customdried
8. customthe solvent was evaporated under reduced pressure