Phenyl Isothiocyanate → HCID 54323585, compound

HRID 344347Notes

Reaction equation

HRID 344347 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11]1)=[O:7])(C)(C)C.[C:18]1([N:24]=[C:25]=[S:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[NH2:27][C:28]1[C:36]([Cl:37])=[CH:35][C:31](C(O)=O)=[C:30]([O:38][CH3:39])[CH:29]=1>>[NH2:27][C:28]1[C:36]([Cl:37])=[CH:35][C:31]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][C:25]([NH:24][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[S:26])[CH2:11]2)=[O:7])=[C:30]([O:38][CH3:39])[CH:29]=1

Participants

4

Reactant 3

HCID 7673Phenyl IsothiocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53652257tert-Butyl ((1-(2-aminoethyl)pyrrolidin-3-yl)methyl)carbamate

Product 1

HCID 54323585HCID 54323585, compound

Procedure

2-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)ethylamine (1 g) as starting compound was reacted and treated in the same manner as in Example 34 using phenyl isothiocyanate (0.49 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.83 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(2-(3-phenylthioureido)ethyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-eb6ef075482344f9a8184921de4235af
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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