Methane → HCID 178488765, compound

HRID 34444Notes

Reaction equation

HRID 34444 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[C:15]3[CH:16]=[CH:17][CH2:18][O:19][C:14]=3[C:13]([O:20][CH3:21])=[C:12]([O:22][CH3:23])[CH:11]=2)=[CH:4][N:3]=1.[O:24]=[C:25]1[O:31][C@H:30]([C@H:32]([CH2:34][OH:35])[OH:33])[C:28]([OH:29])=[C:26]1[OH:27].C>CO>[O:24]=[C:25]1[O:31][C@H:30]([C@H:32]([CH2:34][OH:35])[OH:33])[C:28]([O-:29])=[C:26]1[OH:27].[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[C:15]3[CH:16]=[CH:17][CH2:18][O:19][C:14]=3[C:13]([O:20][CH3:21])=[C:12]([O:22][CH3:23])[CH:11]=2)=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 297MethaneHCID 128497722,4-diamino-5-(7,8-dimethoxy-2H-1-benzopyran-5-ylmethyl)pyrimidineHCID 54670067L-Ascorbic Acid

Product 1

HCID 178488765HCID 178488765, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To 2,4-diamino-5-(7,8-dimethoxy-2H-1-benzopyran-5-ylmethyl)pyrimidine (5.00 g, 15.9 mmol) in 450 mL of boiling methanol was added a solution of L (+)-ascorbic acid (2.80 g, 15.9 mmol) in 50 mL of methanol. The solution was treated with charcoal, filtered, and evaporated to dryness. Further drying at 40° C. in a vacuum oven gave 7.58 g (97.2%) of the title compound. Anal. Calcd for C16H18H4O3.C6H8O6.H2O: C, 51.97; H, 5.55; N, 11.02. Found: C, 51.95; H, 5.57; N, 11.02.

Workup

  1. filtrationfiltered
  2. customevaporated to dryness
  3. customFurther drying at 40° C. in a vacuum oven

Sources & evidence

ORD record
ord-48cd5ce1833a474c94a5f8f0bde048e8
Source dataset
uspto-grants-1988_08
Patent number
US04761475

Reaction notes

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