反应详情

4-Aminomethyl-4-methoxy-1-(6-oxo-6-phenylhexyl)piperidine dihydrochloride (2.25 g) as starting compound, triethylamine (2.4 ml), 4-amino-5-chloro-2-methoxybenzoic acid (1.16 g), 1-hydroxybenzotriazole (0.815 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (1.16 g) were reacted and treated in the same manner as in Example 270 to give 1.43 g of 4-amino-5-chloro-2-methoxy-N-((4-methoxy-1-(6-oxo-6-phenylhexyl)piperidin-4-yl)methyl)benzamide.

1. customwere reacted
2. additiontreated in the same manner as in Example 270