1,2-Dibromoethane → 1-Ebio

HRID 344681Notes

Reaction equation

HRID 344681 reaction equation
[CH2:1]([N:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:4]1=[O:12])[CH3:2].Br[CH2:14][CH2:15][Cl:16].BrCCBr>O1CCCC1>[CH2:1]([N:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]([CH2:14][CH2:15][Cl:16])[C:4]1=[O:12])[CH3:2].[CH2:1]([N:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:4]1=[O:12])[CH3:2]

Participants

6

Reactant 3

HCID 78391,2-DibromoethaneHCID 78491-Bromo-2-ChloroethaneHCID 823201-Ebio

Product 2

HCID 823201-EbioHCID 152357162-(3-ethyl-2,3-dihydro-2-oxo-1H-benzimidazol1-yl)ethyl chloride

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

When an equivalent amount of 3-ethyl-2-benzimidazolinone is substituted for 1-ethoxycarbonyl-2H-indazolin-3-one and 2-bromochloroethane is substituted for 1,2-dibromoethane in the procedure of Example 19 using tetrahydrofuran as solvent, 2-(3-ethyl-2,3-dihydro-2-oxo-1H-benzimidazol1-yl)ethyl chloride is isolated after column chromatography (3-ethyl-2-benzimidazolinone, Aldrich, 6%, A).

Sources & evidence

ORD record
ord-d37a5e5e28b3461f99039a87156b426e
Source dataset
uspto-grants-1991_10
Patent number
US05053411

Reaction notes

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