反应详情

Ethylene glycol (0.3 ml), p-toluenesulphonic acid (1 mg) were added to a solution of (2S)-1-[3-(N-benzyl-N-methylcarbamoyl)propanoyl]pyrrolidin-2-al (164 mg) in benzene (3 ml). The mixture was refluxed for 1 hr. The reaction solution was poured into a saturated aq. solution of sodium bicarbonate. The mixture was extracted with benzene. The extract was washed, dried, and evaporated. The residue was purified by column chromatography on silica gel (CH3OH--EtOAc--CH2Cl2) to give the title compound (79 mg) having the following physical data:

1. temperatureThe mixture was refluxed for 1 hr
2. extractionThe mixture was extracted with benzene
3. washThe extract was washed
4. customdried
5. customevaporated
6. customThe residue was purified by column chromatography on silica gel (CH3OH--EtOAc--CH2Cl2)