反应详情

A 5.0 g portion of calcium pantothenate was slurred in 100 ml of acetone:2,2-dimethoxypropane (1:1). Trifluoroacetic acid (3.0 ml) was added until solution was complete and stirring was continued overnight. A 10 g portion of potassium carbonate was added, this mixture stirred vigorously for 10 minutes and then concentrated to a gummy solid. A 100 ml portion of acetonitrile and 10 ml of methyl iodide were added to the solid. This mixture was stirred for 1 day, then poured into water and extracted twice with ethyl acetate. The extracts were combined, dried and concentrated, giving 4.8 g of the desired compound as a yellow oil.

1. stirringthis mixture stirred vigorously for 10 minutes
2. concentrationconcentrated to a gummy solid
3. additionA 100 ml portion of acetonitrile and 10 ml of methyl iodide were added to the solid
4. stirringThis mixture was stirred for 1 day
5. additionpoured into water
6. extractionextracted twice with ethyl acetate
7. customdried
8. concentrationconcentrated