HRID344764

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

$反应SMILES：CCCCCCCC/C=C\CCCCCCCC(=O)Cl$

HCID5364783

(9Z)-9-Octadecenoyl chloride

C18H33ClO

反应SMILES：CC1(C)OCC(C)(C)C(C(=O)NCCC(=O)NCCN)O1

HCID19805645

未命名化合物

PRODUCTS

产物

$反应SMILES：CCCCCCCC/C=C\CCCCCCCC(=O)NCCNC(=O)CCNC(=O)C1OC(C)(C)OCC1(C)C$

HCID67795484

未命名化合物

收率 19.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A mixture of 1.1 g of N-[3-[(2aminoethyl)amino]-3-oxopropyl]-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide, 1.1 g of oleoyl chloride and 3 ml of triethylamine in 100 ml of tetrahydrofuran was reacted as described in Example 11. The crude product was purified by flash chromatography, eluting with dichloromethane:methane (50:1, then 20:1), giving 400 mg of the desired product as a white solid, mp 110-112° C.

WORKUP

后处理

customwas reacted
customThe crude product was purified by flash chromatography
washeluting with dichloromethane:methane (50:1

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-4c6d257fb8504cc68f765db0fed91d65
来源数据集: uspto-grants-1991_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05053426
来源说明: uspto-grants-1991_10

反应SMILES

[NH2:1][CH2:2][CH2:3][NH:4][C:5](=[O:21])[CH2:6][CH2:7][NH:8][C:9]([CH:11]1[C:16]([CH3:18])([CH3:17])[CH2:15][O:14][C:13]([CH3:20])([CH3:19])[O:12]1)=[O:10].[C:22](Cl)(=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39].C(N(CC)CC)C>O1CCCC1>[CH3:19][C:13]1([CH3:20])[O:12][CH:11]([C:9]([NH:8][CH2:7][CH2:6][C:5](=[O:21])[NH:4][CH2:3][CH2:2][NH:1][C:22](=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[O:10])[C:16]([CH3:17])([CH3:18])[CH2:15][O:14]1