Triethylamine → HCID 67795484, compound

HRID 344764Notes

Reaction equation

HRID 344764 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5](=[O:21])[CH2:6][CH2:7][NH:8][C:9]([CH:11]1[C:16]([CH3:18])([CH3:17])[CH2:15][O:14][C:13]([CH3:20])([CH3:19])[O:12]1)=[O:10].[C:22](Cl)(=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39].C(N(CC)CC)C>O1CCCC1>[CH3:19][C:13]1([CH3:20])[O:12][CH:11]([C:9]([NH:8][CH2:7][CH2:6][C:5](=[O:21])[NH:4][CH2:3][CH2:2][NH:1][C:22](=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[O:10])[C:16]([CH3:17])([CH3:18])[CH2:15][O:14]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 5364783Oleoyl chlorideHCID 19805645HCID 19805645, compound

Product 1

HCID 67795484HCID 67795484, compoundYield 19.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1.1 g of N-[3-[(2aminoethyl)amino]-3-oxopropyl]-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide, 1.1 g of oleoyl chloride and 3 ml of triethylamine in 100 ml of tetrahydrofuran was reacted as described in Example 11. The crude product was purified by flash chromatography, eluting with dichloromethane:methane (50:1, then 20:1), giving 400 mg of the desired product as a white solid, mp 110-112° C.

Workup

  1. customwas reacted
  2. customThe crude product was purified by flash chromatography
  3. washeluting with dichloromethane:methane (50:1

Sources & evidence

ORD record
ord-4c6d257fb8504cc68f765db0fed91d65
Source dataset
uspto-grants-1991_10
Patent number
US05053426

Reaction notes

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