1,3-Propanedithiol → HCID 15020331, compound

HRID 344769Notes

Reaction equation

HRID 344769 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:13])([CH3:12])[C@@H:7]([OH:14])[C@@H:6]2[N:15]=[N+]=[N-])#[N:2].C(N(CC)CC)C.C(S)CCS>CO>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:13])([CH3:12])[C@@H:7]([OH:14])[C@@H:6]2[NH2:15])#[N:2]

Participants

5

Reactant 3

HCID 80131,3-PropanedithiolHCID 8471TriethylamineHCID 86745117HCID 86745117, compound

Product 1

HCID 15020331HCID 15020331, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of trans-5-cyano-1,1-dimethyl-3-azido-indan-2-ol (0.93g), triethylamine (1.2 ml) and 1,3-propanedithiol (0.9 ml) in dry methanol (20 ml) was stirred at room temperature for 48h. After filtration, the solution was evaporated in vacuo to give the title compound (0.79g) as a gum.

Workup

  1. filtrationAfter filtration
  2. customthe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-9337b30c5a31462b9be6b7f46ca11645
Source dataset
uspto-grants-1991_10
Patent number
US05053427

Reaction notes

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