反应详情

A mixture of 1-(4-methoxy-5,6,7,8-tetrahydro-1-naphthyl)-1-butanone (2.50g), paraformaldehyde (0.42g), pyrrolidine hydrochloride (1.51g), and hydrochloric acid (0.2 ml) in isopropyl alcohol (7 ml) was refluxed for 15 hrs. The reaction mixture was evaporated in vacuo to give the residue. The residue was partitioned into water and ethyl ether. The aqueous layer, was extracted, neutralized with ammonia water, and then extracted with ethyl ether. The organic layer was dried over anhydrous magnesium sulfate. The mixture was filtered and the filtrate was evaporated in vacuo to give 1-(4-methoxy-5,6,7,8-tetrahydro-1-naphthyl)-2-ethyl-3-pyrrolidino-1-propanone (2.13 g, Yield: 62.8 %) as an oil.

1. temperaturewas refluxed for 15 hrs
2. customThe reaction mixture was evaporated in vacuo
3. customto give the residue
4. customThe residue was partitioned into water and ethyl ether
5. extractionThe aqueous layer, was extracted
6. extractionextracted with ethyl ether
7. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
8. filtrationThe mixture was filtered
9. customthe filtrate was evaporated in vacuo