Ammonia → HCID 5327706, compound

HRID 345656Notes

Reaction equation

HRID 345656 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:24])[O:13][C:14](=O)[C:15]=2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=2)=[CH:3]1.[NH3:25]>CN(C=O)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:24])[NH:25][C:14](=[O:13])[C:15]=2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=2)=[CH:3]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21615652HCID 21615652, compound

Product 1

HCID 5327706HCID 5327706, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

0.30 g of 3-(1-methyl-3-indolyl)-4-(3-methylphenyl) furan-2,5-dione was treated with 8 ml of DMF and 60 ml of 33% aqueous ammonia and heated at 150° C. for 5 hours and then allowed to cool. The formed precipitate was filtered off, washed with water and dried to give 162 mg of 3-(1-methyl-3-indolyl)-4-(3-methylphenyl)-1H-pyrrole-2,5-dione, m.p. 243° C.

Workup

  1. temperatureto cool
  2. filtrationThe formed precipitate was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-00008f917bc542ec87072683ed7dc023
Source dataset
uspto-grants-1991_10
Patent number
US05057614

Reaction notes

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