Methylamine → HCID 18780265, compound

HRID 345692Notes

Reaction equation

HRID 345692 reaction equation
Br[CH2:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6]1.[CH3:14][NH2:15]>C(O)C>[CH3:14][NH:15][CH2:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 118590271-(3-Bromopropyl)indole

Product 1

HCID 18780265HCID 18780265, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3 g of 1-(3-bromopropyl)indole were treated with a 33% solution of methylamine in ethanol. The resulting solution was stirred for 6 hours. The solvent was evaporated and the residue was dissolved in 50 ml of dichloromethane and washed with a saturated sodium bicarbonate solution. The organic phase was dried and evaporated to give 2.30 g of 1-(3-methylaminopropyl)indole.

Workup

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in 50 ml of dichloromethane
  3. washwashed with a saturated sodium bicarbonate solution
  4. customThe organic phase was dried
  5. customevaporated

Sources & evidence

ORD record
ord-49fcbaa3aa6d44e88b0abf230c6c41ed
Source dataset
uspto-grants-1991_10
Patent number
US05057614

Reaction notes

Loading…