反应详情

16.5 g of potassium carbonate are added to a solution of 37.7 g of ethyl 2-(2-chloro-3,5-difluoro-4-methylbenzoyl)-3-cyclopropylamino-acrylate in 100 ml of anhydrous dimethylformamide. The reaction mixture is then stirred under reflux for 2 hours and poured hot onto ice. The precipitate is filtered off with suction, washed thoroughly with water and dried in vacuo over calcium chloride at 100° C. 30.4 g of ethyl 1-cyclopropyl-6,8-difluoro-7-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylate of melting point 177°-179° C. are obtained.

1. temperatureunder reflux for 2 hours
2. additionpoured hot onto ice
3. filtrationThe precipitate is filtered off with suction
4. washwashed thoroughly with water
5. dry with materialdried in vacuo over calcium chloride at 100° C