Acetyl chloride → HCID 21868329, compound

HRID 346094Notes

Reaction equation

HRID 346094 reaction equation
[C:1]12([C:11]([OH:13])=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C(Cl)(=O)C>CO>[CH3:1][C:11]([OH:13])=[O:12].[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 132351-Adamantanecarboxylic acid

Product 1

HCID 21868329HCID 21868329, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Stir 1.0 mol of adamantane carboxylic acid in 600 ml of methanol. Under ice cooling, drop 1.53 mol of acetyl chloride into the solution within 1 h. Remove the ice bath, and allow the reaction mixture to reach room temperature. Subsequently, heat for 3 hrs under reflux. Evaporate the reaction mixture to dryness under vacuum and distill. (Yield: 97%).

Workup

  1. customRemove the ice bath
  2. customto reach room temperature
  3. temperatureSubsequently, heat for 3 hrs
  4. temperatureunder reflux
  5. customEvaporate the reaction mixture to dryness under vacuum
  6. distillationdistill

Sources & evidence

ORD record
ord-1cc69044c42e4aca89f6ec3faf2da774
Source dataset
uspto-grants-1991_10
Patent number
US05061703

Reaction notes

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