1,1'-Carbonyldiimidazole → HCID 54232870, compound

HRID 346218Notes

Reaction equation

HRID 346218 reaction equation
C1N=CN(C(N2C=NC=C2)=O)C=1.[N:13]1([CH2:19][C:20]([OH:22])=O)[CH2:17][CH2:16][CH2:15][C:14]1=[O:18].[O:23]1[CH2:28][CH2:27][N:26]([C:29]([CH2:31][N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[O:30])[CH2:25][CH2:24]1>C(Cl)Cl>[N:13]1([CH2:19][C:20]([N:35]2[CH2:36][CH2:37][N:32]([CH2:31][C:29]([N:26]3[CH2:25][CH2:24][O:23][CH2:28][CH2:27]3)=[O:30])[CH2:33][CH2:34]2)=[O:22])[CH2:17][CH2:16][CH2:15][C:14]1=[O:18]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 1006221-(Morpholinocarbonylmethyl)piperazineHCID 31466872-(2-Oxopyrrolidin-1-yl)acetic acid

Product 1

HCID 54232870HCID 54232870, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

CDI (2.43 g, 0.015 moles) was added to 1.72 g (0.012 moles) of (pyrrolidin-2-one-1-yl) acetic acid in 40 ml of CH2Cl2 under stirring and after one hour morpholinocarbonylmethyl piperazine 2.56 g, 0.012 moles) was added. The solution was kept under stirring for 20 hours at room temperature, the solvent was then evaporated and the residue chromatographed on silica gel using CHCl3 --MeOH as eluant, ratio 95:5.

Workup

  1. additionwas added
  2. customthe solvent was then evaporated
  3. customthe residue chromatographed on silica gel

Sources & evidence

ORD record
ord-4b245ab223a543f890143d07ce476ea6
Source dataset
uspto-grants-1991_10
Patent number
US05061725

Reaction notes

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