反应详情

A mixture of 100 g (0.549 mole) of methylvanillate, 172.8 g (1.1 mole) of 1-bromo-3-chloropropane and 228 g (1.65 mole) of anhydrous potassium carbonate in 1 L of acetone was heated at reflux for 20 hr. The mixture was cooled, filtered, and the filtrate concentrated to give a white solid as residue. The solid was triturated with petroleum ether, collected by filtration, and dried to yield 137.8 g (97%) of title compound as a white powder, mp 104°-105° C. (2-propanol).

1. temperaturewas heated
2. temperatureat reflux for 20 hr
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. concentrationthe filtrate concentrated
6. customto give a white solid as residue
7. customThe solid was triturated with petroleum ether
8. filtrationcollected by filtration
9. customdried