反应详情

A mixture of 40.0 g (0.29 mole) of 4-methoxybenzylamine (98%, Aldrich) and 150 mL of 48% hydrobromic acid (Baker) was stirred and heated at reflux for 18 hr, then stirred at ambient temperature for 72 hr. The precipitate was collected by filtration, washed with ethyl ether (300 mL) and dried to give 21.0 g (35%) of the title compound as an off-white solid, mp 215°-217° C.

1. temperatureheated
2. temperatureat reflux for 18 hr
3. stirringstirred at ambient temperature for 72 hr
4. filtrationThe precipitate was collected by filtration
5. washwashed with ethyl ether (300 mL)
6. customdried