N-Methylaniline → N-{4-[(3-iodophenyl)amino]quinazoline-6-yl}-4-(methylamino)-2-butenamide

HRID 346421Notes

Reaction equation

HRID 346421 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:20](=[O:27])[CH:21]=[CH:22][CH2:23][N:24](C)[CH3:25])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.CNC1C=CC=CC=1>>[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:20](=[O:27])[CH:21]=[CH:22][CH2:23][NH:24][CH3:25])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7515N-MethylanilineHCID 68562749N-{4-[(3-iodophenyl)amino]quinazoline-6-yl}-4-(dimethylamino)-2-butenamide

Product 1

HCID 69420828N-{4-[(3-iodophenyl)amino]quinazoline-6-yl}-4-(methylamino)-2-butenamide

Procedure

N-{4-[(3-iodophenyl)amino]quinazoline-6-yl}-4-(methylamino)-2-butenamide was prepared as described above in Compound 5, using methylaniline instead of dimethylamine in step (ii).

Sources & evidence

ORD record
ord-bf068f66c82e4be791691495db42806e
Source dataset
uspto-grants-2007_02
Patent number
US07172749B2

Reaction notes

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