Pyrrolidine → HCID 21080215, compound

HRID 346462Notes

Reaction equation

HRID 346462 reaction equation
[C:1]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=O)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:1]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:12])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

Product 1

HCID 21080215HCID 21080215, compound

Procedure

7.97 g (37.0 mmol) BOC-L-proline and 3.09 ml (37.0 mmol) pyrrolidine were coupled according to procedure A. Yield of crude product 11.9 g. The product was purified with a silica column using 2.5–5% methanol in dichloromethane as eluent. Yield 8.31 g (31.0 mmol 84%).

Workup

  1. customThe product was purified with a silica column

Sources & evidence

ORD record
ord-2a337921ad174bd6af8f1767357fd481
Source dataset
uspto-grants-2007_02
Patent number
US07173024B2

Reaction notes

Loading…