Hydrochloric Acid → HCID 6401638, compound

HRID 346496Notes

Reaction equation

HRID 346496 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][NH2:9])=[CH:4][CH:3]=1.[N+:10]([C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=1)([O-:12])=[O:11].Cl.C1COCC1>O>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][NH:9][C:17](=[O:18])[C:16]2[CH:15]=[CH:14][C:13]([N+:10]([O-:12])=[O:11])=[CH:21][CH:20]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 61084-Nitrobenzoic AcidHCID 8028TetrahydrofuranHCID 1007873-Chloro-6-hydrazinopyridazine

Product 1

HCID 6401638HCID 6401638, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of (6-chloropyridazin-3-yl)hydrazine, 4-nitrobenzoic acid, WSCD hydrochloride and THF was stirred at room temperature for 2 hours. The reaction solution was combined with water, and the precipitate was collected by filtration, washed with water and diethyl ether to obtain N′-(6-chloropyridazin-3-yl)-4-nitrobenzohydrazide. To this, acetic acid was added, and the mixture was stirred at 110° C. for 2 hours, the reaction solution was concentrated under reduced pressure, and the resultant crude crystal was washed with ethanol to obtain 6-chloro-3-(4-nitrophenyl)-1,2,4-triazolo[4,3-b]pyridazine. Dat (F:276).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-cea7d13a22e143b08d77e5af45c0665a
Source dataset
uspto-grants-2007_02
Patent number
US07173033B2

Reaction notes

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