HCID 178515985, compound → HCID 178515987, compound

HRID 346513Notes

Reaction equation

HRID 346513 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]3[N:16]=[C:15]([OH:17])[CH:14]=[CH:13][CH:12]=3)=[N:9][N:10]=2)[N:7]=1>N1CCCCC1>[N:16]1([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([C:11]4[N:16]=[C:15]([OH:17])[CH:14]=[CH:13][CH:12]=4)=[N:9][N:10]=3)[N:7]=2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1

Participants

3

Reactant 1

HCID 178515985HCID 178515985, compound

Product 1

HCID 178515987HCID 178515987, compoundYield 142.8%

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 6-(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)pyridin-2-ol (960 mg) and piperidine (10 ml) was stirred at 100° C. for 3 hours. After allowing to cool to room temperature, the reaction solution was concentrated under reduced pressure, and the resultant crystalline residue was recrystallized from ethanol to obtain 6-(6-piperidin-1-yl-1,2,4-triazolo[4,3-b]pyridazin-3-yl) pyridin-2-ol (820 mg) as grayish white crystals.

Workup

  1. temperatureto cool to room temperature
  2. concentrationthe reaction solution was concentrated under reduced pressure
  3. customthe resultant crystalline residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-9d9e3498353a43309334b9cfe6148cf4
Source dataset
uspto-grants-2007_02
Patent number
US07173033B2

Reaction notes

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