反应详情

0.46 g (0.01 mmol) of sodium methoxide is added under argon to tetrahydrofuran (solution A). Then 1.00 g (0.01 mmol) of methyl cyanomethyl(methyl)carbamate from Example 9A is added to 1.73 g (0.02 mmol) of ethyl formate. Solution A is slowly added dropwise to this mixture. The mixture is stirred at RT overnight. The solvent is concentrated in vacuo in a rotary evaporator, and diethyl ether is added to the residue. The crystals which have separated out are filtered off with suction and dried under high vacuum.

1. concentrationThe solvent is concentrated in vacuo in a rotary evaporator, and diethyl ether
2. additionis added to the residue
3. customThe crystals which have separated out
4. filtrationare filtered off with suction
5. customdried under high vacuum