Bromoacetic Acid → HCID 21298296, compound

HRID 34668Notes

Reaction equation

HRID 34668 reaction equation
[C:1]([NH:4][C:5]1[S:9][C:8]([SH:10])=[N:7][CH:6]=1)(=[O:3])[CH3:2].Br[CH2:12][C:13]([OH:15])=[O:14]>CN(C=O)C>[C:1]([NH:4][C:5]1[S:9][C:8]([S:10][CH2:12][C:13]([OH:15])=[O:14])=[N:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6227Bromoacetic AcidHCID 178474367HCID 178474367, compound

Product 1

HCID 21298296HCID 21298296, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.48 g (20 mmol) of 5-acetamido-2-mercapto-1,3-thiazole were dissolved in 90 ml of dry DMF, 2.78 g (20 mmol) of bromoacetic acid were added, and the mixture was stirred at room temperature for 2 hours. The solvent was then removed in vacuo, and the solid residue was washed with diethyl ether. After recrystallization from isopropanol/diethyl ether, 3.1 g (67%) of the title compound were obtained.

Workup

  1. customThe solvent was then removed in vacuo
  2. washthe solid residue was washed with diethyl ether
  3. customAfter recrystallization from isopropanol/diethyl ether

Sources & evidence

ORD record
ord-f59bb8b3a7974d5f8e86eb075a8f8b98
Source dataset
uspto-grants-1988_08
Patent number
US04762848

Reaction notes

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