反应详情

A solution of 1.0 g of 1-(2-furanylcarbonyl)-4-(2-chloroethyl)piperazine and 200 mg of sodium iodide in 40 ml of methanol which contained 25% of methylamine was reacted at 70° C. in a sealed tube for 24 hours. After allowing the reaction mixture to cool down, the reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: a 20:1:0.1 mixture of chloroform, methanol, and methanol containing 40% methylamine) to give 800 mg of crystals (yield: 82%).

1. customwas reacted at 70° C. in a sealed tube for 24 hours
2. temperatureto cool down
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. customthe residue was purified by column chromatography on silica gel (eluent
5. additiona 20:1:0.1 mixture of chloroform, methanol, and methanol containing 40% methylamine)