Hydrochloric Acid → HCID 21082645, compound

HRID 347317Notes

Reaction equation

HRID 347317 reaction equation
[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]3[CH:16]=[C:17]([CH:20]4OCC[O:21]4)[S:18][CH:19]=3)[CH:5]=[CH:4][C:3]1=2.Cl.CO>C1COCC1>[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]3[CH:16]=[C:17]([CH:20]=[O:21])[S:18][CH:19]=3)[CH:5]=[CH:4][C:3]1=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21082602HCID 21082602, compound

Product 1

HCID 21082645HCID 21082645, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A round bottom flask was mixed with 2-{4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-2-thienyl}-1,3-dioxolane (5.1 g, 14.3 mmol), 3.0 N HCl (50 mL), methanol (20 mL) and THF (30 mL). The reaction mixture stirred for 6 hours at room temperature and was concentrated to one half volume. The resulting mixture was partitioned between water and ether. The ether layer was dried over MgSO4 and concentrated to dryness. The resulting oil showed an inseparable impurity by TLC from the starting material. The product was used without further purification (2.7 g).

Workup

  1. concentrationwas concentrated to one half volume
  2. customThe resulting mixture was partitioned between water and ether
  3. dry with materialThe ether layer was dried over MgSO4
  4. concentrationconcentrated to dryness
  5. customThe product was used without further purification (2.7 g)

Sources & evidence

ORD record
ord-66751e21d6874eb3a1bfcdeed8cf37b9
Source dataset
uspto-grants-2007_02
Patent number
US07173134B2

Reaction notes

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