Azepane → HCID 86597563, compound

HRID 347595Notes

Reaction equation

HRID 347595 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[CH:4][N:3]=1.[NH:14]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>C1COCC1>[N:14]1([C:2]2[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[CH:4][N:3]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 8119AzepaneHCID 757382-Chloro-3,5-dinitropyridine

Product 1

HCID 86597563HCID 86597563, compoundYield 41.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

3 g (14.7 mmol) of 2-chloro-3,5-dinitropyridine, 10 ml of THF and 30 mmol of azepane were placed in a round-bottomed flask. The mixture was maintained at 60° C. for 15 hours with stirring and was then poured into an ice-water mixture with stirring. The precipitate formed was filtered off by suction and dried under vacuum to constant weight. 1.64 g of yellow powder were obtained.

Workup

  1. stirringwith stirring
  2. customThe precipitate formed
  3. filtrationwas filtered off by suction
  4. customdried under vacuum to constant weight

Sources & evidence

ORD record
ord-ea810eefe5c740e988aa0d340246ad32
Source dataset
uspto-grants-2007_02
Patent number
US07175670B2

Reaction notes

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