反应详情

To a solution of methyl 6-(bromomethyl)nicotinate from Example G1 (2.0 g, 8.60 mmol) in DMF (15 ml) was added sodium azide (0.84 g, 12.9 mmol). The mixture was stirred at room temperature for 18 h. EtOAc (100 ml) was added and the mixture was washed with water (3 times), dried over MgSO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica (eluant EtOAc:pet ether 20:80) to give a yellow gum; yield 1.55 g (93%).

1. washthe mixture was washed with water (3 times)
2. dry with materialdried over MgSO4
3. concentrationconcentrated in vacuo
4. customThe residue was purified by flash chromatography on silica (eluant EtOAc:pet ether 20:80)
5. customto give a yellow gum