反应详情

To a solution of methyl 6-(tert-butyloxycarbonylaminomethyl)nicotinate from Example G3 (1.56 g, 5.84 mmol) in THF (20 ml) and water (5 ml) was added lithium hydroxide monohydrate (0.37 g, 8.76 mmol). The mixture was stirred at room temperature for 18 h and then concentrated in vacuo. The aqueous residue was acidified by addition of 1M citric acid solution and extracted with chloroform/IPA (3 times). The combined organic extracts were washed with brine, dried over MgSO4, and evaporated in vacuo to give a white solid; yield 1.38 g (94%).

1. concentrationconcentrated in vacuo
2. additionThe aqueous residue was acidified by addition of 1M citric acid solution
3. extractionextracted with chloroform/IPA (3 times)
4. washThe combined organic extracts were washed with brine
5. dry with materialdried over MgSO4
6. customevaporated in vacuo
7. customto give a white solid