Iodoethane → 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-

HRID 347646Notes

Reaction equation

HRID 347646 reaction equation
[O:1]=[C:2]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3]1.[CH2:13](I)[CH3:14]>>[CH2:13]([N:8]1[C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3][C:2]1=[O:1])[CH3:14]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 2237712,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Product 1

HCID 30782002H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-

Procedure

2-Oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (1.95 g, 11.96 mmol) was reacted with ethyl iodide (1.4 ml, 17.5 mmol) according to the procedure in Example 18A. The product was purified by flash chromatography on silica (eluant EtOAc); yield 1.70 g (75%).

Workup

  1. customThe product was purified by flash chromatography on silica (eluant EtOAc)

Sources & evidence

ORD record
ord-c59cc29e10ad497786d80d9cece45616
Source dataset
uspto-grants-2007_02
Patent number
US07176195B2

Reaction notes

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