Hydrochloric Acid → HCID 21083979, compound

HRID 347921Notes

Reaction equation

HRID 347921 reaction equation
Cl.[CH2:2]([N:4]=[C:5]=[O:6])[CH3:3].[O:7]=[C:8]1[N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:12]2[S:20][C:21]([NH:29]C(N)=O)=[C:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:11]=2[CH:10]=[CH:9]1>>[CH2:2]([NH:4][C:5]([NH:29][C:21]1[S:20][C:12]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:8](=[O:7])[CH:9]=[CH:10][C:11]=2[C:22]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:6])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8022Ethyl isocyanateHCID 21083988HCID 21083988, compound

Product 1

HCID 21083979HCID 21083979, compound

Procedure

The title compound was prepared from the HCl salt of the compound of Example 81 and ethyl isocyanate following the method described for the compound of Example 97 to give the product as a solid (24 mg). δH (DMSO-d6) 8.59 (1H,s), 7.8–7.4 (11H, m), 6.67 (1H, t, J 5 Hz), 6.38 (1H, d, J 10 Hz), 3.1–2.9 (2H, m), 0.97 (3H, t, J 7 Hz). LCMS (ES+) 390 (M+H)+.

Sources & evidence

ORD record
ord-f6e81635f45e4dfa9db778aae26e0a93
Source dataset
uspto-grants-2007_02
Patent number
US07176215B2

Reaction notes

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